Key Publications

Cox, N., Pilling, D., and Gomer, R.H.  DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.  Proc. Natl. Acad. Sci. USA, 112, 8385-8390 (2015).

Karhadkar, T.R., Pilling, D., Cox, N., and Gomer, R.H.  Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model. Scientific Reports, 7, 15069 (2017).

Karhadkar, T.R., Chen, W., and Gomer, R.H.  Attenuated pulmonary fibrosis in sialidase-3 knockout (Neu3-/-) mice.  American Journal of Physiology-Lung Cellular and Molecular Physiology, 318, L165-L179 (2020).

Chen, W., Lamb, T.R., and Gomer, R.H.  TGF-β1 Increases Sialidase 3 Expression in Human Lung Epithelial Cells by Decreasing its Degradation and Upregulating its Translation.  Experimental Lung Research, 46, 75-80 (2020).

Chen, W., Karhadkar, T.R., Ryu, C., Herzog, E.L., and Gomer, R.H.  Reduced sialylation and bioactivity of the anti-fibrotic protein serum amyloid P in the sera of patients with idiopathic pulmonary fibrosis.  ImmunoHorizons, 4, 352-362 (2020).

Pilling, D., Karhadkar, T.R., and Gomer, R.H.  A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the methionine and choline-deficient (MCD) diet.  PLoS ONE, 15, e0244762 (2020).

Pilling, D., Karhadkar, T.R., and Gomer, R.H.  High-fat diet-induced adipose tissue and liver inflammation and steatosis in mice are reduced by inhibiting sialidases.  American Journal of Pathology, 191, 131-143 (2021).

Karhadkar, T.R., Meek, T.D., and Gomer, R.H.  Inhibiting sialidase-induced TGF-β1 activation attenuates pulmonary fibrosis in mice.  Journal of Pharmacology and Experimental Therapeutics, 376, 106-117 (2021).

Pilling, D., Sahlberg, K., Karhadkar, T.R., Chen, W., and Gomer, R.H.  The sialidase NEU3 promotes pulmonary fibrosis in mice.  Respiratory Research, 23, 215 (2022).

Kirolos, S.A., Pilling, D., and Gomer, R.H.  The extracellular sialidase NEU3 primes neutrophils.  J. Leukocyte Biology 112, 1399-1411 (2022). 

Pilling, D., Sahlberg, K., Chen, W., and Gomer, R.H.  Changes in lung sialidases in male and female mice after bleomycin aspiration.  Experimental Lung Research, 48, 291-304 (2022).

Karhadkar, T.R., Chen, W., Pilling, D., and Gomer, R.H. Inhibitors of the Sialidase NEU3 as Potential Therapeutics for Fibrosis.  Int. J. Mol. Sci. 24, 239 (2023).

Chen, W., Pilling, D., and Gomer, R.H.  The mRNA binding protein DDX3 mediates TGF-β1 upregulation of translation and promotes pulmonary fibrosis.  Journal of Clinical Investigation Insight, in press.